What is L-Serine ?
L-Serine is one of the naturally occurring proteinogenic Amino Acids. Its codons are UCU, UCC, UCA, UCG, AGU and AGC. Only the L-stereoisomer appears naturally in proteins. It is not essential to the human diet, since it is synthesized in the body from other metabolites, including glycine. Serine was first obtained from silk protein, a particularly rich source, in 1865. Its name is derived from the Latin for silk, sericum. Serine's structure was established in 1902. By virtue of the hydroxyl group, serine is classified as a polar Amino Acid.Serine (abbreviated as Ser or S) is an organic compound with the formula.
The biosynthesis of serine starts with the oxidation of 3-phosphoglycerate to 3-phosphohydroxypyruvate and NADH. Reductive amination of this ketone followed by hydrolysis gives serine. Serine hydroxymethyltransferase catalyzes the reversible, simultaneous conversions of L-serine to glycine (retro-aldol cleavage) and 5,6,7,8-tetrahydrofolate to 5,10-methylenetetrahydrofolate (hydrolysis).
Function
1. Precursors of synthesis of purine, thymine and choline;
2. L-serine hydroxyl can generate phosphoserine with important physiological functions after phosphorylation, and it is one of the main components of phospholipid.
3. It has the function of stabilizing the pH value of eye drops and has no stimulation after eye drops;
4. One of the important natural Moisturizing factors (NMF), the primary role of the cuticle in moisture retention, and a key additive in advanced cosmetics.
Application
1. Medical raw materials: serine is widely used in the configuration of third-generation compound amino acid infusion and nutritional supplement, and in the synthesis of various silk amino acid derivatives, such as cardiovascular, anti-cancer, AIDS new drugs and protective amino acids used in genetic engineering;
2. Food: serine is used in sports drinks, amino acid diet drinks, etc.
3. Feed: serine is used in animal feed to promote animal growth and development.
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